![]() ![]() 5-ASA therapy resulted in clinical remission in 50% (4/8) of patients, but no correlation with changes in fecal bacteria was observed. Fecal microbiota were analyzed by 16S rDNA high-throughput sequencing, and clinical indices were used to assess the efficacy of treatments. ![]() Sixteen patients with active left-sided UC underwent enema treatment using 5-ASA ( n = 8) or FMT ( n = 8) with a stool from a single donor. The aim of this study was to identify changes in fecal bacterial composition after both types of treatments and evaluate clinical responses. The administration of aminosalicylates (5-ASA) is a conventional treatment that targets the mucosa, while fecal microbial transplantation (FMT) is a novel treatment that directly targets the gut microbiota. ![]() Ulcerative colitis (UC) is an inflammatory bowel disease, and intestinal bacteria are implicated in the pathogenesis of this disorder. ![]()
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